基于五运六气理论对新型冠状病毒感染肺炎的几点思考

基于五运六气理论,尤其是三年化疫理论,对当前正在流行的新型冠状病毒感染的肺炎进行病因病机分析及分期诊疗指导。     

新护士护患沟通能力欠缺原因分析

加强培养新护士沟通能力是医改新形势下护理管理者应倍加关注的课题。新护士沟通能力的欠缺主要表现为意识不强、内容不全、技巧不成熟和保密观念不牢等，原因涉及个体、社会经历的缺失、医患关系变化等多方面；建议把新护士沟通能力的培养融入进在职培训中，同时重视营造人文关怀氛围。     

8周基础军训对入伍新兵红细胞及其相关指标的影响

目的探讨8周基础军训(basic military training,BMT)对入伍新兵血像中红细胞及其相关指标的影响,为指导科学的军事训练提供参考。方法数据来自新疆边防部队2015年度入伍的50名男性新兵,分别在BMT前后测定并记录受试新兵的红细胞计数、血红蛋白浓度及血清铁蛋白等。结果经过8周的BMT,新兵血液中血红蛋白浓度、红细胞计数及血清铁蛋白均显著下降(P0.05,P0.01)。结论 8周BMT可能导致入伍新兵发生运动性贫血,铁缺乏可能是其主要原因。     

基于“5P-3L”创新管理模式的泌尿外科新药临床试验团队建设及培训经验浅谈

目的：随着国家对新药临床试验核查要求的提高，建立一支专业化的新药临床试验研究团队和形成一套完善的管理模式，成为提高新药临床评价质量的有效途径。本文结合近些年泌尿外科专业组的工作经验逐渐摸索形成了一个"5P-3L"新药临床试验创新管理模式，制定了一套较为完善的培训体系，从人员管理、培训、奖励机制等各个方面加强人才培养和团队建设，最终提高新药临床试验研究水平。     

Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

Drug repurposing is an efficient strategy for new drug discovery. Our latest study found that nitazoxanide (NTZ), an approved anti-parasite drug, was an autophagy activator and could alleviate the symptom of Alzheimer's disease (AD). In order to further improve the efficacy and discover new chemical entities, a series of NTZ-based derivatives were designed, synthesized, and evaluated as autophagy activator against AD. All compounds were screened by the inhibition of phosphorylation of p70S6K, which was the direct substrate of mammalian target of rapamycin (mTOR) and its phosphorylation level could reflect the mTOR-dependent autophagy level. Among these analogs, compound 22 exhibited excellent potency in promoting β-amyloid (Aβ) clearance, inhibiting tau phosphorylation, as well as stimulating autophagy both in vitro and in vivo. What's more, 22 could effectively improve the memory and cognitive impairments in APP/PS1 transgenic AD model mice. These results demonstrated that 22 was a potential candidate for the treatment of AD.     

Review of expandable dental implants

In the last few years the dental implants market has grown both in developed and developing countries, and is associated with high aesthetic expectations and well-being. Although the success rate of commercial implants is high, some problems associated with a lack of initial stability, marginal bony resorption, and periodontal health, remain, especially with immediate placement and loading. The market offers different designs of dental implants, but cylindrical and tapered devices that are fixed to the bone via an external thread are dominant. One lesser-known but potentially useful design is the expandable dental implant (EDI). This paper presents a review of expandable dental implants that encompasses a survey of the literature, published patents, and available commercial devices. We found 15 articles: prospective human trials (n = 4), human case reports (n = 3), published independent discussions of other articles (n = 2), three big animal trials (n = 3), and in silico studies (n = 3). A total of 73 published patents were found and two expandable dental implants are commercially available to date. We propose a classification system that differentiates between the expansion mechanism and the origin of the expanding action. Some expandable designs have been shown to provide good primary stability, but evidence to date is limited. We encourage future clinical and biomechanical studies to clarify and optimise the potential benefits of these implants.     

新媒体环境下健康科普视频的创作与传播策略研究

《"健康中国2030"规划纲要》将普及健康知识作为主要目标之一,健康科普已成为公众关注的重要领域,而新媒体已成为公众获取健康知识的主要平台。该研究根据新媒体环境下用户和信息传播的特点,以健康科普视频为实例,制定并研究健康科普视频的创作模式和传播策略,以期对新媒体环境下健康信息普及、公众健康素养提升提供借鉴。     

失血性休克紧急手术模拟演练在新入职护士培训中的应用效果分析

目的:探讨失血性休克紧急手术模拟演练在新入职护士培训中的应用效果。方法:选取2019年医院外科手术室新入职护士31人为对照组,另选2020年医院新入职护士31人为观察组,对照组实施常规培训方法,观察组在对照组基础上实施失血性休克紧急手术模拟演练,比较两组应用效果。结果:干预后观察组护士急救相关核心制度、急救抢救药物知识、抢救流程、紧急手术各类应急预案评分均高于对照组(P<0.05);干预后观察组护士除颤仪、呼吸机、心肺复苏仪、徒手心肺复苏操作技能评分均高于对照组(P<0.05);干预后观察组护士抢救配合能力、案例分析能力、应急处理能力、学习兴趣、沟通能力评分均高于对照组(P<0.05);观察组护士工作能力优良率为96.77%,高于对照组的70.97%(P<0.05)。结论:失血性休克紧急手术模拟演练应用于新入职护士培训中,不仅可有效提高其理论知识水平、操作技能及综合能力,还能提高其工作能力优良率。